LEVITRA PHARMACOKINETICS

Vardenafil is rapidly absorbed with approximately 15% absolute bioavailability. A single 20 mg dose of Levitra in healthy volunteers leads to maximum observed plasma concentrations between 30 minutes and 2 hours after oral administration in an empty stomach. In other food-effects, studies showed that fatty meals caused a reduction in C max by 18%-50%. The plasma concentrations measurement in healthy male volunteers after 20 mg dose oral administration is depicted in the picture below.

Vardenafil is approximately 95% bound to plasma proteins. This protein binding is reversible and independent of total drug concentrations. After 1.5 hours of dosing of20 mg Vardenafil dose, a mean of 0.00018% was found in semen of healthy volunteers. Hepatic enzyme CYP3A4 primarily metabolizes Vardenafil along with involvement of the CYP3A5 and CYP2C isoforms. Vardenafil is excreted as metabolites mainly around 91-95% of the dose taken in the feces and 2-6% of the dose taken in the urine.

The table below concludes all the chemical details of Vardenafil;